The waste spark system runs 2 spark plugs on 1 coil in the coil pack, to do that the spark plugs are connected in series, + to - to + to -
What this means is that 1 spark plug has a normal center electrode to ground electrode spark, but the other one has a ground electrode to center spark, reverse spark, but still a spark.
The reverse spark tends to be weaker.
But because of the temperature differences in the spark plugs on the compression stroke(cooler) and the exhaust stroke(hotter) most of the spark power goes to the least resistant spark plug, the cooler one, compression stroke, so in most cases the weaker reverse spark is not an issue.
The 12volts is always at the coil(key on), the ground path is used to allow voltage to flow thru the primary windings in the coil, this was the same setup that was used in the distributor and points system, "-" controlled the coil power.
If a coil dies completely, yes, 2 spark plugs will go with it, but if it is running out of spec then it might effect only one spark plug in the pair.
Could be the driver in the ignition module(PCM) limiting voltage at the primary coil so less spark voltage is available, or wire to coil(or connectors) is reducing voltage, or inside the coil there could be a problem.
For general P030x misfires it could be lower or higher resistance in one spark plug of the pair, this could be in the secondary windings in the coil or spark plug wire or spark plug.
When radios, and now sensors and computers, were added to vehicles solid conductor spark plug wires(0 resistance) had to go, too much noise and interference.
Higher resistance spark plug wires are used now to reduce this noise...and spark voltage.
Spark plugs can also have resistors built-in which are said to reduce noise but are really there to save the electrodes, not that it matters, lol.
On distributor setups resistance wasn't as much of an issue, one spark plug one spark, unless it got way out of spec.
With the waste spark system and knowing electricity travels to the path of least resistance and that two spark plugs are sharing the same path/coil............it can be a different story.
If one of the spark plugs or wires has higher resistance, then the other plug/wire will get most of the spark voltage each time coil fires, making for a weak spark in one cylinder.
This is easy to test for with an OHM meter, but heat changes things, so cold test won't always ID a problem.