A multi-spark discharge ignition only "shines" when introduced to more "violent" combustion chambers. In order for the electrons to jump the gap of a spark plug, they must overcome the resistance created by air and fuel in the combustion chamber. The stock ignition will likely be adequate for stock "conditions". When you increase the compression of your engine or you run forced induction then the pressures in the cylinder increase, and so does the resistance. When this happens, you should upgrade the ignition system.
I have no personal experience with the 2.9L specifically, but I do run an MSD-6AL on my V8 ranger. It is a nice addition but only needed when the rest of the engine is upgraded first. Some might argue that you will get better gas mileage and a little more power out of the multi-spark function. And you will, with a high performance engine. But for a stock or almost-stock 2.9L I really doubt you will notice much. After all, if multi-spark discharge and higher voltage gave stock engines better economy AND more power then Ford would have integraded this into the truck already.
So we could help you out with your goal, what are you looking to get out of the truck with an MSD? (Ex. more power, better mileage, reliability...)