As an owner of more than 1 rotary powered RX7, I say go for it. If you intend to have a boosted 2 rotor, or any form of 3 rotor, be sure you step up to the factory turbo transmission. Speaking of transmission, the non-turbo trans from an 81-91 RX7 looks almost identical to the TK5 used in older rangers, aside from the bellhousing. Stands to reason, as Toyo Kogyo is the corporate name for Mazda...... As such, the shifter location will be pretty close to the same as the truck, and they already have a fairly short throw shifter. Naturally, there are short-throw shifters available for these transmissions.
Rearend gearing will need to be in the 4.10-4.56 range if you plan to drive it much on the highway, of course, tire size will also factor into this equation. Stock gearing for most rotary cars was 3.90-4.30, boosted or not. The rotary trucks were geared much lower, 4.56-5.13 or thereabouts. The lower gearing was to help overcome the taller tires, along with added load carrying capacity.
I've considered swapping the 2.3 in my B2300 for a 13B if/when the 2.3 dies. If I were to do this, I'd most likely do something similar to this:
That's my 84 RX7. 6 port 13B with Edelbrock 600, header, and custom ignition system using 3 GM HEI's and 3 coils to fire 4 plugs. Boost is nice, but I love the simplicity of old school N/A stuff.
I know it doesn't seem logical to put a 600 CFM carb on a 1308cc (1.3L) engine, but I truely believe this engine could stand even more carb.......