Clean antifreeze can be reused. Use a clean bucket or pan to catch it, and move it under the lower radiator hose when you remove that (more antifreeze will come out). I know you said that yours hasn't been changed in several years, but you've been adding fresh, so the old can be reused if needed.
>>> You'll most likely lose some antifreeze, so you'll need to have some on hand. That being said, there's two options:
1 Get your repair made, make sure everything is OK, and then plan on changing the antifreeze later.
2 Go ahead and put new antifreeze back in.
I'd opt the second, if the budget allows. You'll need to check your local rules for disposing the old; it's considered hazardous waste. A lot parts stores will take old antifreeze for recycling.
A drained cooling system won't be hurt by cold temperatures.
I'd get the old radiator out of the way first, then do the thermostat. There'll be a little more room to work.
A new radiator cap would be a good idea. If the old cap looks good it would be OK to use, however. If you put a new cap on, you may want to keep the old as as an emergecy spare.
The old radiator, completely drained, can be thrown in the dumpster.
Other random thoughts:
If the old hoses are stuck, get a spray can with a tube of WD-40 lubricant. It can help break the bond of the old hose rubber to the metal parts, and it can help some with stuck bolts. It's handy for other stuff, too.
Be careful handling and installing the new radiator. The fins of the cooling tubes are easily bent, which will reduce the radiator's effectiveness. I like wrapping and taping a peice of cardboard around the finned area, front and back over the top, then slipping it off right before I bolt the radiator in.
You'll also lose a little automatic transmission fluid (ATF), so you may need a bottle of it, to top the fluid level after you're done. Be sure to check the ATF level afterward (it's covered in your truck's owners manual). Have a pair of baggies and rubber bands on hand when you remove the ATF lines from the radiator; put the baggies over the open ends of the lines and wrap the rubber band to hold it place. This will help reduce the fluid loss while they're open, and help keeping them clean before reinstallation.
You'll have questions as you go, and that's to be expected. Be careful, take your time.
Good luck!